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第 19 筆
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論文名稱: | 蜆（Corbicula fluminea）萃取物及水解物對脂質氧化與脂氧合酶活性之影響
| Effect of Corbicula fluminea extracts and hydrolysates on lipid oxidation and lipoxygenase activities
研究生: | 廖靜伃 L iao-Ching Yu
指導教授: | 孫寶年
學位類別: | 碩士
學校名稱: | 國立臺灣海洋大學
系所名稱: | 食品科學系
學號: | M91320017
畢業學年度: | 92
語文別: | 中文
關鍵字: | 蜆 freshwater clam
| 脂氧合酶 lipoxygenase
| 抗氧化 antioxidation
全文點閱次數: | 20

全文影像連結:

論文全文(pdf)

論文頁數: | 63
摘要: | 摘  要
|
| 台灣的淡水貝類養殖以台灣蜆（Corbicula fluminea）為主，本研究為測定蜆萃取物、水解物之抗氧化性及生理活性，其中以抑制脂氧合酶（LOX）能力作為抗腫瘤、活血、預防動脈粥樣硬化功效之初步評估指標，並以市售蜆精作為對照。
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| 蜆之處理分為：生蜆之熱水抽出物（FC-W）、生蜆、和蜆肉殘渣（FC-WR）之有機溶劑（甲醇、乙酸乙酯、甲醇-乙酸乙酯）萃取物六種，及 FC-WR 之 Protamex 水解物，分別以掃除自由基（DPPH）及抑制血紅素催化亞麻油酸自氧化評估抗氧化性。於 12 月採收較其他季節的蜆之熱水萃取物抑制亞麻油酸自氧化能力高，半抑制濃度（IC50）為 ascorbic acid 之 640 倍。蜆肉乾物經 Protamex 水解後產物抑制亞麻油酸自氧化之 IC50 為未水解前之 67%。所有測試之蜆萃取物清除自由基能力與添加量呈正相關（dose-dependent），以台糖蜆精和蜆熱水萃取物之 IC50 值最小，為生蜆之甲醇-乙酸乙酯萃取物的 19.4 %，仍均低於 ascorbic acid 之千分之一，蜆肉乾物之乙酸乙酯萃取物則無清除自由基之能力。蜆之有機溶劑萃取物的抗氧化效力均低於蜆之水溶性萃取物 74% 以下。以冷光法測蜆萃取物對 15-LOX（黃豆 LOX 1）之抑制能力，作為對預防動脈粥樣硬化之初步評估指標，以 12 月採收的蜆之熱水萃取物 IC50 低於3、9月採收者，為 NDGA 之519 倍。蜆之水溶性萃取物對抑制 15-LOX 能力普遍均較有機溶劑萃取物高，與其抗氧化力相似。
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論文目次: | 目  錄
| 目錄………………………………………………………………………...Ⅰ
| 圖目錄……………………………………………………………………...Ⅲ
| 表目錄……………………………………………………………………...Ⅳ
| 英文摘要…………………………………………………………………...Ⅴ
| 中文摘要…………………………………………………………………...Ⅶ
| 壹、前言……………………………………………………………………1
| 貳、文獻回顧………………………………………………………………3
| （一）台灣蜆………………………………………………………………3
| （二）貝類萃取物…..……………………………………………………..6
| 1.    成分…………………………………………………………………….6
| 2.    抗氧化性……………………………………………………………….7
| （三）抗氧化劑對紅血球與血液黏度之影響..…………………………..8
| （四）脂氧合酶之特性及生理意義……………………………..………..9
| 1.    脂氧合酶與發炎及過敏反應之關係………………………...……...10
| 2.    脂氧合酶與腫瘤之關係……………...………………………...……12
| 3.    脂氧合酶與動脈粥樣硬化之關係………………………………..…14
| 參、材料與方法……………………………………………………...…...17
| （一）材料…………………………………………………………..……17
| （二）蜆肉乾物、熱水及有機溶劑萃取物與水解物之製備…..……....17
| （三）蜆測試原液之製備……………………………………...………...19
| （四）蜆萃取物及水解物對脂質氧化之抑制……………….………….23
| 1.    抑制亞麻油酸自氧化…………………………………...…………...23
| 2.    清除自由基（DPPH）………………………………...…………….24
| （五）脂氧合酶活性之測定—冷光測定法……………..………………25
| （六）半抑制濃度之計算………………………………..………………25
| 肆、結果與討論…………………………………………..………………...26
| （一）　蜆萃取物之產率…………………..……………………………….26
| 1.    市售蜆精與熱水萃取物……………………………………………...26
| 2.    蜆肉殘渣及生蜆肉之萃取物………………………………………...27
| （二） 蜆萃取物及水解物之抗氧化性……………..…………………….29
| 1.    抑制亞麻油酸自氧化………………………………………………...29
| 2.    清除自由基（DPPH）…………………………………………………36
| （三） 蜆萃取物及水解物對脂氧合酶之抑制—氫過氧化物之生成.......41
| 伍、結論…………………………………………………………………….45
| 陸、參考文獻……………………………………………………………….47
|
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2009 年 11 月 22 日 23:43